She also teamed with Sara Wolff, Shaggy Abolian and Casey Sripramong to win the 200 freestyle relay with a CIF consideration time of 1:48.93. Sher swam her leading two laps in a school-record time of 25.10.
Sher, who also won the 200 individual medley (2:14.97) and helped the Nitros (3-0) win the 200 medley relay, keeps many of the school swimming records in a binder in her backpack.
She marveled at her mark in the 500.
"It feels really nice to break records," said Sher, who teamed with Ani Hovhannisyan, Sripramong and Wolff to take the 200 medley relay (2:00.97) and is a member of the Pasadena-based Rose Bowl Aquatics Club. "It's an honor and fun to race and have the speed to encourage people.
"It's exciting to break my sister's record because I respect her and she's encouraged me. I just go out there and do what I can."
Glendale swept all 11 events in the match to drop the Rebels to 0-2.
Sripramong, who helped the Glendale's girls' water polo team advance to the semifinals of the CIF Southern Section Division IV semifinals in February, won the 50 freestyle (26.79) and the 100 butterfly (1:06.14).
Other winners for the Nitros included Rachel Hahn in the 200 freestyle (2:14.86) and Wolff in the 100 freestyle (59.1). Lily Broussard captured the 100 backstroke (1:11.17) for the Nitros, who got a first-place effort from Hovhannisyan in the 100 breaststroke (1:15.90).
Wolff, Jade Wilia, Hahn and Broussard teamed up to win the 400 freestyle relay (4:10.75).
The boys' meet proved to be dramatic.
Glendale (1-1) raced out to a 56-36 lead midway through the meet before Flintridge Prep (0-2) made a late surge that fell just short.