The stabbing occurred about 7:30 p.m. in the 1000 block of Western Avenue in Glendale following a road-rage incident that began on the freeway, Sgt. Tom Lorenz said.
The victim had been driving north on the I-5 freeway when he was cut off by another vehicle, he said.
After he and the other vehicle exited on Western Avenue, they stopped at a red light at the intersection with San Fernando Road. It was there that the man and a woman, who was a passenger in the other vehicle, yelled profanity at each other, Soboleski said.
The light turned green and both cars continued on Western Avenue. But then the motorist blocked the victim's car near his home, Lorenz said.
They exited their cars and began yelling and fighting, he said. During the fight, police said the victim was stabbed.
The motorist fled the scene, but the victim got a description of the vehicle, which was described as an older gold or silver El Camino with a yellow California license plate issued from 1956 to 1962. The license plate numbers and letters were black.
The motorist was described as a slim white man, about 35 to 45 years old, blond medium-length hair, and between 5 foot 10 inches to 6 foot 2 inches tall. He wore a light-colored shirt and blue jeans.
The passenger was described as a white woman, heavy set, 45 to 50 years old with blond shoulder-length hair.
The victim told police both spoke English and Armenian.
Anyone with details about the attack is urged to call Soboleski at (818) 548-3987 or Glendale Crime Stoppers at (818) 507-7867. To remain anonymous, call the Los Angeles Regional Crime Stoppers' tip line at (800) 222-TIPS.